Et forskerhold fra Mie University i Japan har fundet ud af, at tidlige zebrafiskembryoner (embryoner flere timer efter befrugtning) sikkert kan bestråles med 278 nm UVC.
UVC-LED'er omkring 260 nm bruges til sterilisering, da de inducerer og inaktiverer DNA-skader fra bakterier og vira. Det meste af den nuværende forskning fokuserer på effekten af UVC med bølgelængder under 240nm (207nm, 222nm, 233nm) på at dræbe den nye coronavirus. Der er dog få undersøgelser af organismers toksicitet, sikkerhed og respons på UVC-bestråling omkring 280 nm.
Therefore, this time, a total of 16 irradiation doses were set in the range of 0.5 to 60 mJ/cm² using the irradiation device developed by the research group to irradiate 278 nm UVC, and zebrafish embryos were directly irradiated.
After 3 days of irradiation, the researchers evaluated the survival rate, hatching rate, heart rate, deformity rate, etc. of zebrafish embryos. The results found that all embryos remained alive under the irradiation dose below 4.5mJ/cm². However, when the dose reached 7.5 mJ/cm², the deformity rate significantly increased to 82 percent , and the survival rate decreased to 37 percent . Embryo death was observed if the dose was increased to 10 mJ/cm² and above.
Based on the above experimental results, the researchers determined that there is a biological defense system inside the zebrafish embryo, which can resist the damage caused by UVC irradiation to the greatest extent, and the limit dose that can resist UVC irradiation is 4.5 mJ/cm².
The researchers believe that the biological defense mechanism of zebrafish against UVC-induced DNA damage is that after zebrafish embryos are treated with UVC at a dose of 4.5 mJ/cm², the p53 signaling pathway in cells is immediately and urgently activated. Arrest, DNA repair, cell division/proliferation and damaged cell death in rapid response to stress. In addition, after 3 days of recovery, p53 variability was attenuated and instead activated the STAT signaling pathway, which continued to repair damaged DNA.
Forskningsresultaterne for dette emne giver et videnskabeligt grundlag for sikkerheden ved UVC-LED påført på den menneskelige krop. Samtidig fandt forskerholdet ud af, at UVC er velegnet til desinfektion af bakterier og vira, herunder coronavirus, samt desinfektion i akvakultur.
"Experts say UV" believes that: at the application level, the sterilization experience of UVC-LED is difficult to intuitively perceive, and consumers will have concerns about safety when using it. brings confidence.
GMKJ LED-teknologi er dybt involveret i sunde og smarte lyskilder, og forsyner markedet med et komplet udvalg af UVA UVB UVC LED, infrarøde IR LED VCSEL-produkter og -løsninger og har hundredvis af-højkvalitetspartnere i indenlandske og udenlandske markeder for i fællesskab at fremme brugen af lysteknologi til at skabe et sundt og smart liv. årsag.
